The protein-resistant properties of Dursan were studied using quartz crystal microbalance with dissipation monitoring (QCM-D), and compared to that of bare stainless steel and a Teflon-like fluoropolymer coating (AF1600).
With the assistance of a nonionic surfactant-containing wash solution, Dursan® was found to facilitate 100% removal of adsorbed proteins (BSA, mouse IgG and NHP), whereas these proteins remain adsorbed on the bare stainless steel surface under same conditions.
Stainless steel is commonly used throughout LC systems, including needles, columns, pump components, and tubing. Bio-analytical samples interact with metal surfaces and leached metal ions; contaminating the sample and causing inaccurate results.
The common solution to this problem has historically been use of PEEK or other inert non-metallic materials. PEEK, glass and other inert materials have several drawbacks:
Dursan® corrosion resistant coating prevents sampling component damage and contamination throughout the analytical flow path. Dursan can coat the ID of the smallest needles, improving durability and preventing protein binding to stainless steel surfaces.
Typical coating after bleach exposure | Dursan after bleach exposure |
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